- Mass Spectrometry
- Ca Isotopes
Calcium Isotope Analysis by Mass Spectrometry
Sergei F. Boulyga
Safeguards Analytical Laboratory, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer Strasse 5, 1400 Vienna, Austria
Mass Spectrometry Reviews (2010), V29, pp685– 716, doi:
Goal: The variations in the isotopic composition of calcium caused by fractionation in heterogeneous systems and by nuclear reactions can provide insight into numerous biological, geological, and cosmic processes, and therefore isotopic analysis finds a wide spectrum of applications in cosmo- and geochemistry, paleoclimatic, nutritional, and biomedical studies. The measurement of calcium isotopic abundances in natural samples has challenged the analysts for more than three decades.
- Triton: Ca isotopes
Calcium Isotope Composition of Meteorites, Earth, and Mars
Justin I. Simon (1), Donald J. DePaolo (1) and Frederic Moynier (2)
1) Center for Isotope Geochemistry, Earth and Planetary Science, University of California, Berkeley, CA 94720, USA, 2) Earth and Planetary Sciences and McDonnell Center for Space Sciences, Washington University in St Louis, MO 63130, USA
The Astrophysical Journal (2009), V702, pp707–715, doi: 10.1088/0004-637X/702/1/707
Goal: The relative abundances of calcium isotopes in the mass range 40–44 were measured in primitive and differentiated meteorites and igneous rocks from Earth and Mars in search of non-mass-dependent variations that could provide clues about early solar system processes. Most bulk samples of planetary materials have calcium isotopic compositions identical with Earth’s within the current resolution of about 0.01% in 40Ca/44Ca. Possible exceptions include carbonaceous chondrites, some ordinary chondrites, and two samples of calcium–aluminumrich inclusions, which have small excesses of 40Ca.
- Ca isotopes
Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes
Jennifer L. L. Morgan (1,3), Joseph L. Skulan (2), Gwyneth W. Gordon (2), Stephen J. Romaniello (2) Scott M. Smith (3) and Ariel D. Anbara (2)
1) Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, 85287, USA; 2) School of Earth and Space Exploration, Arizona State University, Tempe, AZ, 85287, USA; 3) Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration, Houston, TX, 77058, USA
Proceedings of the National Academy of Science of the United States of America (2012), V109(25), pp9989–9994, doi:10.1073/pnas.1119587109
Goal: The ability to rapidly detect changes in bone mineral balance (BMB) would be of great value in the early diagnosis and evaluation of therapies for metabolic bone diseases such as osteoporosis and some cancers. However, measurements of BMB are hampered by difficulties with using biochemical markers to quantify the relative rates of bone resorption and formation and the need to wait months to years for altered BMB to produce changes in bone mineral density large enough to resolve by X-ray densitometry. We show here that, in humans, the natural abundances of Ca isotopes in urine change rapidly in response to changes in BMB. In a bed rest experiment, use of high-precision isotope ratio MS allowed the onset of bone loss to be detected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to be detectable with densitometry.
- Ca isotopes
High-Precision Measurement of Variations in Calcium Isotope Ratios in Urine by Multiple Collector Inductively Coupled Plasma Mass Spectrometry
Jennifer L. L. Morgan (1), Gwyneth W. Gordon (2), Ruth C. Arrua (2), Joseph L. Skulan (3), Ariel D. Anbar (1,2) Thomas D. Bullen (4)
1) Arizona State University, Department of Chemistry and Biochemistry, P.O. Box 871604, Tempe, Arizona 85287, United States, 2) Arizona State University, School of Earth and Space Exploration, P.O. Box 871404, Tempe, Arizona 85287, United States, 3) University of Wisconsin, Geology Museum, 1215 West Dayton Street, Madison, Wisconsin 53706, United States, 4) Water Resources Discipline, U.S. Geological Survey, 345 Middlefield Road, Menlo Park, California 94025, United States
Analytical Chemistry (2011), V83(18), pp6956-62, doi: 10.1021/ac200361t
Goal: We describe a new chemical separation method to isolate Ca from other matrix elements in biological samples, developed with the long-term goal of making highprecision measurement of natural stable Ca isotope variations a clinically applicable tool to assess bone mineral balance. A new two-column procedure utilizingHBr achieves the purity required to accurately and precisely measure two Ca isotope ratios (44Ca/42Ca and 44Ca/43Ca) on a Neptune multiple collector inductively coupled plasmamass spectrometer (MC-ICPMS) in urine.
- Triton: Ca isotopes
Experimental identification of Ca isotopic fractionations in higher plants
Florian Cobert (1), Anne-Désirée Schmitt (2), Pascale Bourgeade (2), François Labolle (3), Pierre-Marie Badot (2), François Chabaux (1), Peter Stille (1)
1) Laboratoire d’Hydrologie et de Ge´ochimie de Strasbourg, Université de Strasbourg/EOST, CNRS, 1 rue Blessig, F-67000 Strasbourg, France, 2) Université de Franche-Comté et CNRS-UMR 6249, Chrono-environnement, 16, Route de Gray, 25030 Besanc on Cedex, France, 3) Université de Strasbourg, Institut de Zoologie et de Biologie générale, 12, rue de l’Université , 67000 Strasbourg, France
Geochimica et Cosmochimica Acta (2011), V75, pp5467–5482, doi: 10.1016/j.gca.2011.06.032
Goal: Hydroponic experiments have been performed in order to identify the co-occurring geochemical and biological processes affecting the Ca isotopic compositions within plants. To test the influence of the Ca concentration and pH of the nutritive solution on the Ca isotopic composition of the different plant organs, four experimental conditions were chosen combining two different Ca concentrations (5 and 60 ppm) and two pHs (4 and 6). The study was performed on rapid growing bean plants in order to have a complete growth cycle.
- Ca isotopes
Calcium-isotope fractionation in selected modern and ancient marine carbonates
Thomas Steuber (1,2) and Dieter Buhl (1)
1) Ruhr-Universität, Institut für Geologie, Mineralogie und Geophysik, 44801 Bochum, Germany, 2) The Petroleum Institute, P.O. Box 2533, Abu Dhabi, UAE.
Geochimica et Cosmochimica Acta (2006), V70, pp5507–5521, doi: 10.1016/j.gca.2006.08.028
Goal: The calcium-isotope composition (d44/42Ca) was analyzed in modern, Cretaceous and Carboniferous marine skeletal carbonates as well as in bioclasts, non-skeletal components, and diagenetic cements of Cretaceous and Carboniferous limestones. In order to gain insight in Ca2+ aq–CaCO3-isotope fractionation mechanisms in marine carbonates, splits of samples were analyzed for Sr, Mg, Fe, and Mn concentrations and for their oxygen and carbon isotopic composition.
- Ca isotopes
- High Resolution
High precision calcium isotope ratio measurements using a magnetic sector multiple collector inductively coupled plasma mass spectrometer
Michael E. Wieser (1,3), Dieter Buhl (2), Claudia Bouman (1) and Johannes Schwieters (1)
1)Thermo Electron (Bremen) GmbH, Barkhausenstr. 2, 28197, Germany, 2) Institut für Geologie Mineralogie und Geohphysik, Ruhr Universität Bochum, Universitätsstr. 150, 44801, Germany, 3) University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
Journal of Analytical Atomic Spectrometry (2004), V19, pp844-851, doi: 10.1039/b403339f
Goal: Calcium isotope abundances were measured using a Finnigan Neptune magnetic sector multiple collector inductively coupled plasma mass spectrometer capable of resolving all molecular isobaric interferences from 42Ca, 43Ca, 44Ca, 46Ca and 48Ca. Scattering events caused by the intense 40Ar+ ion beam did not contribute to the uncertainty in the baseline of the calcium mass spectrum. Quantitative separation of the calcium from the sample matrix was carried out to ensure that the measurements were independent of the sample type. In addition, thorough desolvation of the aerosol was found to have a significant effect on the stability and sensitivity of the method.
- Triton Plus
- Boron Isotopes
A high-throughput system for boron microsublimation and isotope analysis by total evaporation thermal ionization mass spectrometry
Yi-Wei Liu (1), Sarah M. Aciego (1), Alan D. Wanamaker Jr. (2) and Bryan K. Sell (1)
1) Earth and Environmental Sciences, University of Michigan, 1100 N. University Avenue, Ann Arbor, MI 48109, USA, 2) Department of Geological and Atmospheric Sciences, Iowa State University, Ames, IA 50011, USA
Rapid Communications in Mass Spectrometry (2013), V27, pp1705–1714, doi: 10.1002/rcm.6619
Goal: Research on the ocean carbon cycle is vitally important due to the projected impacts of atmospheric CO2 on global temperatures and climate change, but also on ocean chemistry. The direct influence of this CO2 rise on the seawater pH can be evaluated from the boron isotopic composition in biogenic carbonates; however, conscientious laboratory techniques and data treatment are vital in obtaining accurate and precise results. A rapid-throughput boron purification and Total Evaporation Thermal Ionization Mass Spectrometry method was developed for high accuracy and precision boron isotopic analysis for small (ng) sample sizes
- Positive TIMS
- B isotopes
An improved procedure for separation/purification of boron from complex matrices and high-precision measurement of boron isotopes by positive thermal ionization and multicollector inductively coupled plasma mass spectrometry
Hai-Zhen Wei (1), Shao-Yong Jiang (1,2), N. Gary Hemming (3,4), Jing-Hong Yang (1), Tao Yang (1), He-Pin Wu (1), Tang-Li Yang (1), Xiong Yan (1), Wei Pu (1)
1) State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, PR China, 2)State Key Laboratory of Geological Processes and Mineral Resources, Faculty of Earth Resources, China University of Geosciences, Wuhan, Hubei 430074, PR China, 3) Department of Earth and Environmental Sciences, Lamont-Doherty Earth Observatory of Columbia University, Palisades, NY 10964-8000, USA, 4) Queens College School of Earth and Environmental Sciences, Flushing, NY 11367, USA
Talanta (2014) , V123, pp151–160, doi: 10.1016/j.talanta.2014.02.009
Goal: In order to eliminate boron loss and potential isotopic fractionation during chemical pretreatment of natural samples with complex matrices, a three-column ion-exchange separation/purification procedure has been modified, which ensures more than 98% recovery of boron from each step for a wide range of sample matrices, and is applicable for boron isotope analysis by both TIMS and MC-ICP-MS.
- B isotopes
- Laser Ablation
Determination of boron isotope compositions of geological materials by laser ablation MC-ICP-MS using newly designed high sensitivity skimmer and sample cones
Lin Lin (1), Zhaochu Hu (1a), Lu Yang (2), Wen Zhang (1), Yongsheng Liu (1), Shan Gao (1), Shenghong Hu (1)
1) State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China, 2) Measurement Science and Standards, National Research Council Canada, Ottawa, Ontario K1A 0R6, Canada
Chemical Geology (2014), V386, pp22-30, doi: 10.1016/j.chemgeo.2014.08.001
Goal: The effects of addition of nitrogen gas with use of three different combinations of sample and skimmer cones on the performance of LA-MC-ICP-MS for in situ B isotope ratio measurements were investigated in detail.
- B isotopes
- Direct Injection
A fully automated direct injection nebulizer (d-DIHEN) for MC-ICP-MS isotope analysis: application to boron isotope ratio measurements
Pascale Louvat, Julien Moureau, Guillaume Paris, Julien Bouchez, Johanna Noireaux and Jérôme Gaillardet
Institut de Physique du Globe de Paris, Sorbonne Paris Cité, Université Paris-Diderot, UMR CNRS 7154, 1 rue Jussieu, 75238, France
Journal of Analytical Atomic Spectrometry (2014), V29, pp1698-1707, doi: 10.1039/c4ja00098f
Goal: This work presents a fully automated setup for using direct injection nebulization as an introduction system for solution measurements by MC-ICP-MS, here applied to boron isotopes in pure boric acid solutions and natural samples. In this setup, a direct injection nebulizer (d-DIHEN) is plugged into the plasma torch without any spray chamber, and an automated 6-port valve interfaces the nebulizer and the autosampler. The advantages of a d-DIHEN for boron isotope ratio measurements are high sensitivity and short washout times, allowing for sample–standard bracketing (SSB) measurements at a higher rate than spray chambers.
- B isotopes
- Marine Carbonates
Rapid, high-precision measurements of boron isotopic compositions in marine carbonates
Malcolm T. McCulloch (1,2), Michael Holcomb (1,2), Kai Rankenburg (2) and Julie A. Trotter (2)
1) The University of Western Australia, School of Earth and Environment and ARC Centre of Excellence in Coral Reef Studies, Crawley 6009, Western Australia, Australia, 2) The University of Western Australia, School of Earth and Environment and Oceans Institute, Crawley 6009, Western Australia, Australia
Rapid Communications in Mass Spectrometry (2014), v28, pp1–9, doi: 10.1002/rcm.7065
Goal: The isotopic composition and elemental abundance of boron (B) in marine carbonates provide a powerful tool for tracking changes in seawater pH and carbonate chemistry. Progress in this field has, however, been hampered by the volatile nature of B, its persistent memory, and other uncertainties associated with conventional chemical extraction and mass spectrometric measurements. Here we show that for marine carbonates, these limitations can be overcome by using a simplified, low-blank, chemical extraction technique combined with robust multi-collector inductively couple plasma mass spectrometry (MC-ICPMS) methods.
- Laser Ablation
- Boron Isotopes
A Review on the determination of Isotope Ratios of Boron with Mass Spectrometry
Suresh Kumar Aggarwal (1,2) and Chen-Feng You (2,3)
1) Fuel Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India, 2)Department of Earth Sciences, National Cheng Kung University, Tainan, Taiwan, 3) Earth Dynamic System Research Centre, NCKU, Taiwan
Mass Spectrometry Reviews (2016), V9999, pp1–21, doi: 10.1002/mas.21490
Goal: The present review discusses different mass spectrometric techniques—viz, thermal ionization mass spectrometry (TIMS), inductively coupled plasma mass spectrometry (ICPMS), and secondary ion mass spectrometry SIMS)—used to determine 11B/10B isotope ratio, and concentration of boron required for various applications in earth sciences, marine geochemistry, nuclear technology, environmental, and agriculture sciences, etc.
- B isotopes
- Pore water
Rapid determination of boron isotopic composition (δ11B) in pore water by multi-collector inductively coupled plasma mass spectrometry
Tao Yang (1,2,3), Xiao-Peng Bian (1,3), Bi Zhu (4), Shao-Yong Jiang (1,5,6), Xiong Yan (1) and Hai-Zhen Wei (1)
1) State Key Laboratory for Mineral Deposits Research, Nanjing University, P. R. China, 2) Beijing SHRIMP Center, Institute of Geology Chinese Academy of Geological Sciences, Beijing, P. R. China, 3) Collaborative Innovation Center of South China Sea Studies, Nanjing University, P. R. China, 4) Institute of Isotope Hydrology, School of Earth Sciences and Engineering, Hohai University, Nanjing, P. R. China, 5) State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan, P. R. China, 6) Faculty of Earth Resources and Collaborative Innovation Center for Scarce and Strategic Mineral Resources, China University of Geosciences, Wuhan, P. R. China
Analytical Methods (2016), V8, pp1721-1727, doi: 10.1039/c5ay00613a
Goal: A new method has been developed for the accurate, precise and more rapid determination of boron isotopes (δ11B) by MC-ICP-MS applicable to seawater and pore water samples. Obvious matrix effects have been observed when applying pure standard solutions to bracket the untreated pore water samples and matrix-containing standards. The matrix effects were eliminated by applying matrix-matched standards to measure the matrix-matched ones.
- Br isotopes
Bromine isotope ratio measurements in seawater by multi-collector inductively coupled plasma-mass spectrometry with a conventional sample introduction system
de Gois JS (1,2), Vallelonga P (3), Spolaor A (4), Devulder V (2), Borges DL (1,5), Vanhaecke F (6)
1) Department of Chemistry, Federal University of Santa Catarina, P.O. Box 476, 88040-970, Florianopolis, Santa Catarina, Brazil, 2) Department of Analytical Chemistry, Ghent University, Krijgslaan 281-S12, 9000, Ghent, Belgium, 3) Centre for Ice and Climate, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, 2100, Copenhagen, Denmark, 4) Department of Environmental Sciences, Informatics and Statistics (DAIS), Ca' Foscari University of Venice, Dorsoduro 2137, 30123, Venice, Italy, 5) INCT de Energia & Ambiente, 88040-900, Florianopolis, Santa Catarina, Brazil, 6) Department of Analytical Chemistry, Ghent University, Krijgslaan 281-S12, 9000, Ghent, Belgium
Analytical and Bioanalytical Chemistry (2016), V408(2), pp409-416, doi: 10.1007/s00216-015-8820-1
Goal: A simple and accurate methodology for Br isotope ratio measurements in seawater by multi-collector inductively coupled plasma-mass spectrometry (MC-ICP-MS) with pneumatic nebulization for sample introduction was developed.