March 2019 – GC-IRMS: Combat emerging threats in drug abuse with isotope fingerprints

Drugs in body are converted in metabolites. These metabolites are removed from body in different ways with greatest portion being excreted through the kidneys. The metabolic fate of drug and the excretion time can vary greatly, causing low detectability of drugs in urine. It is important to study metabolism of therapeutic agents to identify metabolites that provide utmost retrospectivity and specificity.

 

This application brief reports how isotope fingerprints have been effectively investigated to detect labeled metabolites of drug of abuse by using gas chromatography isotope ratio mass spectrometry (IRMS).

 

Download the application brief AB30520 from the Knowledge Base.